Vidalista 80 mg includes tadalafil, a PDE5 inhibitor that is intended to treat erectile dysfunction (ED) by increasing blood flow to the penis during sexual activity. However, 80 mg is more than the usually suggested tadalafil dose for ED, therefore it should not be used without medical supervision. Safety is determined by an individual's health, other medications, and proper dose. Tadalafil should not be used with nitrate medications, since this can result in a significant reduction in blood pressure.